Unraveling key steps in the biosynthesis of antimicrobial methylated unsaturated 2-alkyl-4-quinolones of Burkholderia thailandensis
Cell Rep Phys Sci (2024) 5: 102100. DOI: 10.1016/j.xcrp.2024.102100Open Access
Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration
Environ. Int. (2023) 180, 108229. DOI: 10.1016/j.envint.2023.108229Open Access
Biosynthetic flexibility of Pseudomonas aeruginosa leads to hydroxylated2-alkylquinolones with proinflammatory host response
Commun. Chem. (2023) 6 , 138 . DOI: 10.1038/s42004-023-00937-y
Beyond iron: metal-binding activity of the Pseudomonas quinolone signal-motif
Org. Biomol. Chem. (2023) 21: 5158-5163 . DOI: 10.1039/D3OB00710C
A ligand selection strategy to customize small molecule probes for activity-based protein profiling (LS-ABPP)
Methods Enzymol. (2022) 664: 23-58. DOI: 10.1016/bs.mie.2022.01.008
Synthesis of bacterial 2-alkyl-4(1H)-quinolone derivatives
Arkivoc (2021) part ix: 218-239. DOI: 10.24820/ark.5550190.p011.547 Open Access
QSDB—a graphical Quorum Sensing Database.
Database (2021) baab058. DOI: 10.1093/database/baab058
A Metabolite of Pseudomonas Triggers Prophage-Selective Lysogenic to Lytic Conversion in Staphylococcus aureus
J. Am. Chem. Soc. (2021) 143(22): 8344-8351. DOI: 10.1021/jacs.1c01275 Open Access, highlighted as Supplementary Cover
Inhibiting quinolone biosynthesis of Burkholderia
Chem. Sci. (2021) 12: 6908-6912. DOI: 10.1039/D0SC06167K Open Access, highlighted on the back cover
A ligand selection strategy identifies chemical probes targeting the proteases of SARS‐CoV‐2
Angew. Chem. Int. Ed. (2021) 60(12): 6799-6806. DOI: 10.1002/anie.202016113 Open Access
Unveiling the Hidden Theatre of Microbes. (Editorial)
ChemBioChem (2020) 21: 2869-2869. DOI: doi.org/10.1002/cbic.202000554
A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity
Cell Chem. Biol. (2020) 27: 817-826. DOI: 10.1016/j.chembiol.2020.06.004
Competitive profiling for enzyme inhibitors using chemical probes
Methods Enzymol. (2020) 633: 49-67. DOI: 10.1016/bs.mie.2019.10.031
Engineering Siderophores
Methods Enzymol. (2020) 633: 29-47. DOI: 10.1016/bs.mie.2019.10.030
Profiling Structural Diversity and Activity of 2-Alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia
Chem. Commun. (2020) 56: 6328-6331. DOI: 10.1039/D0CC02498H HOT Article, highlighted on the front cover
Competitive metabolite profiling of natural products reveals subunit specific inhibitors of the 20S proteasome.
ACS Cent. Sci. (2020) 6 (2): 241-246. DOI: 10.1021/acscentsci.9b01170 Open Access
The Multifaceted Inhibitory Effects of an Alkylquinolone on the Diatom Phaeodactylum tricornutum
ChemBioChem (2020) 21: 1206-1216 . DOI: 10.1002/cbic.201900612 Open Access
Inhibitors of Bacterial Swarming Behavior
Chem. Eur. J. (2020) 26(5): 964-979. DOI: 10.1002/chem.201901961 Highlighted as reviews showcase and frontpiece
Pseudo-biomineralisation: complex mineral structures shaped by microbes
ACS Biomater. Sci. Eng. (2019) 5(10): 5088-5096. DOI: 10.1021/acsbiomaterials.9b00387
A thiochromenone antibiotic derived from Pseudomonas quinolone signal selectively targets the Gram-negative pathogen Moraxella catarrhalis
Chem. Sci. (2019) 10: 6624-6628. DOI: 10.1039/C9SC01090D Highlighted in the 2019 HOT Article Collection
Close the ring to break the cycle: Tandem quinolone-alkyne-cyclisation gives access to tricyclic pyrrolo[1,2-a]quinolin-5-ones with potent anti-protozoal activity.
Chem. Commun. (2019) 55: 7009-7012. DOI: 10.1039/c9cc01689a Highlighted on the inside back cover
Competitive live-cell profiling strategy for discovering inhibitors of the quinolone biosynthesis of Pseudomonas aeruginosa
J. Am. Chem. Soc. (2018) 140 (43): 14019–14023. DOI: 10.1021/jacs.8b07629
Dissecting the mechanism of oligomerization and macro-cyclization reactions of NRPS independent siderophore synthetases.
Chem. Eur. J. (2018) 24: 16044-16051. DOI: 10.1002/chem.201803494 Highlighted as "hot paper" and cover feature
Eine vielseitige Enzymklasse für die Synthese ringförmiger Siderophore
BIO spektrum (2018) 05.18: 484-487. DOI: 10.1007/s12268-018-0950-5
Correlation of structural features of novel 1,2,3-triazoles with their neurotoxic and tumoricidal properties
Chem.-Biol. Interact. (2018) 291: 253-263. DOI: 10.1016/j.cbi.2018.06.029
A repeating sulfated galactan motif resuscitates dormant Micrococcus luteus
Appl. Environ. Microbiol. (2018) 84: e00745-18. DOI: 10.1128/AEM.00745-18
One Enzyme to Build Them All – Ring-Size Engineered Siderophores Inhibit Swarming Motility of Vibrio
ACS Chemical Biology (2018) 13(5): 1153-1158. DOI: 10.1021/acschembio.8b00084
From pirates and killers: Does metabolite diversity drive bacterial competition?
O rg. Biomol. Chem. (2018) 16: 2814-2819. DOI: 10.1039/c8ob00150b Highlighted on the journal front cover and in the HOT article collection
4-Quinolone N-oxides as bacterial weapons
(Synpacts) Synlett (2018) 29: 542-547. DOI: 10.1055/s-0036-1591913
From Molecules to Life: Quantifying the complexity of chemical and biological systems in the Universe
J . Mol. Evol. (2018) 86: 1-10. DOI: 10.1007/s00239-017-9824-6
An unsaturated quinolone N-Oxide of Pseudomonas aeruginosa modulates growth and virulence of Staphylococcus aureus
Angewandte Chemie Int. Ed. (2017) 56(25): 7271-7275. DOI: 10.1002/anie.201702944 Highlighted as “hot paper” and as journal front cover
Chemical probes for competitive profiling of quorum sensing signal synthase PqsD of Pseudomonas aeruginosa
Beilstein J. Org. Chem. (2016) 12: 2784-2792. DOI: 10.3762/bjoc.12.277
Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa
Chem. Commun . (2016) 52, 13440-13443. DOI: 10.1039/C6CC06295D Highlighted as journal front cover
An Additive Definition of Molecular Complexity
J. Chem. Inf. Model. (2016) , 56(3): 462-470. DOI: 10.1021/acs.jcim.5b00723
Dynamics of snake-like swarming behaviour of Vibrio alginolyticus
Biophys. J. (2016), 110(4): 981-992. DOI: 10.1016/j.bpj.2015.12.037
An aromatic hydroxyamide attenuates multiresistant Staphylococcus aureus toxin expression
Chem. Eur. J. (2016) , 22(5): 1622-1630. DOI: 10.1002/chem.201503981
Wie Bakterien uns mit Naturstoffen krank machen. Nachrichten aus der Chemie
Nachrichten aus der Chemie (2015), 63(12): 1163-1167. DOI: 10.1002/nadc.201590400
Phenyl esters are potent inhibitors of caseinolytic protease P and reveal a stereogenic switch for de-oligomerization
J. Am. Chem. Soc. (2015) , 137(26): 8457-8483. DOI: 10.1021/jacs.5b03084
A Chimeric Siderophore Halts Swarming Vibrio
Angewandte Chemie Int . Ed. (2014) 53(13): 3510-3513. DOI: 10.1002/anie.201310729
A β-Lactone-Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice
ChemMedChem (2014), 9(4):710-713. DOI: 10.1002/cmdc.201300325
Synthesis and Activity of Biomimetic Biofilm Disruptors
J. Am. Chem. Soc. (2013) 135(8): 2927-30. DOI: 10.1021/ja3120955
The mechanism of caseinolytic protease (ClpP) inhibition
Angewandte Chemie Int. Ed. (2013), 52(10): 3009-3014. DOI: 10.1002/anie.201204690
β-Lactams and β-lactones as activity-based probes in chemical biology
Med. Chem. Comm. (2012), 3: 408-417. DOI: 10.1039/c2md00275b
Development and characterization of improved β-lactone-based anti-virulence drugs targeting ClpP
Bioorg. Med. Chem. (2012), 20(2): 583-591. DOI: 10.1016/j.bmc.2011.07.047
Vibralactone as a tool to unravel the activity and structure of the ClpP1P2 complex from Listeria monocytogenes
Angewandte Chemie Int. Ed. (2011), 50(46): 11001-11004. DOI: 10.1002/anie.20
Identification of Acyl Protein Thioesterase 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M
Angewandte Chemie Int. Ed. (2011), 50(42): 9838-9842. DOI: 10.1002/anie.201102967
A conformational switch underlies ClpP protease function
Angewandte Chemie Int. Ed. (2011), 50(25): 5749-5752. DOI: 10.1002/anie.201100666 Highlighted as “hot paper”
Protein reactivity of natural product derived γ-butyrolactones
Biochemistry (2011), 50 (5): 910-916. DOI: 10.1021/bi101858g
The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds
Chem. Commun. (2010), 46: 8475-8477. DOI: 10.1039/c0cc02825h
A cyanobacterial serine protease of Plasmodium falciparum is targeted to the apicoplast and plays an important role in its growth and development
Mol. Microbiol. (2010), 77(6): 873-890. DOI: 10.1111/j.1365-2958.2010.07251.x
Natural products and their biological targets: proteomic and metabolomic labeling strategies
Angewandte Chemie Int. Ed. (2010), 49(15): 2680-2698. DOI: 10.1002/anie.200905352
Showdomycin as a versatile chemical tool for the detection of pathogenesis associated enzymes in bacteria
J. Am. Chem. Soc. (2010), 132(20): 6964-72. DOI: 10.1021/ja909150y
Small Molecules as Versatile Tools for Activity-Based Protein Profiling Experiments
In: Comprehensive Natural Products II: Chemistry and Biology, Vol. 9: Modern Methods for the Investigation of Natural Products (2010), p. 629-674, Ed. Lew Mander, Hung-Wen Liu, Elsevier, ISBN: 9780080453811. DOI: 10.1016/B978-008045382-8.00159-3
Naturstoffe und ihre Derivate als molekulare Sonden: Identifikation ihrer Angriffsziele und Inhibition der Virulenz in pathogenen Bakterien
Verlag Dr. Hut, München (2010). ISBN: 978-3-86853-331-6. DOI: 10.5282/edoc.11018
The HADES mission concept – astrobiological survey of Jupiter's icy moon Europa
Int. J. Astrobiol. (2009), 8(4): 321-329. DOI: 10.1017/S147355040999022X
β-Lactones Decrease the Intracellular Virulence of Listeria monocytogenes in Macrophages
ChemMedChem (2009), 4(8):1260-1263. DOI: 10.1002/cmdc.200900157
Structurally refined beta-lactones as potent inhibitors of devastating bacterial virulence factors
ChemMedChem (2009),10(4):663-666. DOI: 10.1002/cbic.200800743
Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus
J. Am. Chem. Soc. (2008), 130(44): 14400-14401. DOI: 10.1021/ja8051365
Beta-lactones as privileged structures for the active-site labeling of versatile bacterial enzyme classes
Angewandte Chemie Int. Ed. (2009), 47(24): 4600-4603. DOI: 10.1002/anie.200705768
The fate of isoproturon in a freshwater microcosm with Lemna minor as a model organism
Chemosphere (2007), 66: 684-689. DOI: 10.1016/j.chemosphere.2006.07.087