2025
Chitinivorax: The New Kid on the Block of Bacterial 2-Alkyl-4(1H)-quinolone Producers. V. Savchenko, X. A. Yu, M. Polz, T. Böttcher* ACS Chem. Biol. Accepted. (2025) Discovery of the antifungal compound ilicicolin K through genetic activation of the ilicicolin biosynthetic pathway in Trichoderma reesei. I. Burger, M. Schmal, K. Peikert, L. Fourtis, C. Suster, C. Stanetty, D. Schnalzer, B. Hufnagel, T. Böttcher, R. Birner-Gruenberger, R. L. Mach, A. R. Mach-Aigner, M. Schittmayer, C. Zimmermann. Biotechnol. biofuels bioprod. Accepted. 2025-03, Vol.18 (1), p.32, Article 32 (2025) DOI: 10.1186/s13068-025-02628-3 Open Access A quinolone N-oxide selectively targets Neisseria gonorrhoeae via its toxin-antitoxin system. A.-K. Mix, T. H. N. Nguyen, T. Schuhmacher, D. Szamosvári, P. Muenzner, P. Haas, L. Heeb, H. T. Wami, U. Dobrindt, Y. Ö. Delikkafa, T. U. Mayer, T. Böttcher*, C. R. Hauck* Nature Microbiol. Accepted. (2025) DOI: 10.1038/s41564-025-01968-y
Unraveling key steps in the biosynthesis of antimicrobial methylated unsaturated 2-alkyl-4-quinolones of Burkholderia thailandensis
Cell Rep Phys Sci (2024) 5: 102100. DOI: 10.1016/j.xcrp.2024.102100Open Access
The Parkinson's drug entacapone disrupts gut microbiome homeostasis via iron sequestration F. C. Pereira, X. Ge, J. M. Kristensen, R. H. Kirkegaard, K. Maritsch, D. Szamosvári, S. Imminger, D. Seki, J. B. Shazzad, Y. Zu, M. Decorte, B. Hausmann, D. Berry, K. Wasmund, A. Schintlmeister, T. Böttcher, J.-X. Cheng, M. Wagner* Nature Microbiol. (2024) 9: 3165–3183 DOI: 10.1038/s41564-024-01853-0 Open Access Burkholderia pseudomallei produces 2-alkylquinolone derivatives important for host virulence and competition with bacteria that employ naphthoquinones for aerobic respiration S. Mou, V. Savchenko, V. Filz, T. Böttcher, D. DeShazer* Front. Microbiol. (2024) 15:1474033. DOI: 10.3389/fmicb.2024.1474033 Open Access Cooperative binding of bivalent ligands yields new insights into the guanidine-II riboswitch J. Steuer, M. Sinn, F. Eble, S. Rütschlin, T. Böttcher, J. S. Hartig, C. Peter* NAR Genomics and Bioinformatics Vol. 6(3), lqae132 (2024) DOI: 10.1093/nargab/lqae132 Open Access
Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration
Environ. Int. (2023) 180, 108229. DOI: 10.1016/j.envint.2023.108229Open Access
Biosynthetic flexibility of Pseudomonas aeruginosa leads to hydroxylated2-alkylquinolones with proinflammatory host response
Commun. Chem. (2023) 6 , 138 . DOI: 10.1038/s42004-023-00937-y
Beyond iron: metal-binding activity of the Pseudomonas quinolone signal-motif
Org. Biomol. Chem. (2023) 21: 5158-5163 . DOI: 10.1039/D3OB00710C
A ligand selection strategy to customize small molecule probes for activity-based protein profiling (LS-ABPP)
Methods Enzymol. (2022) 664: 23-58. DOI: 10.1016/bs.mie.2022.01.008
Synthesis of bacterial 2-alkyl-4(1H)-quinolone derivatives
Arkivoc (2021) part ix: 218-239. DOI: 10.24820/ark.5550190.p011.547 Open Access
QSDB—a graphical Quorum Sensing Database. K. Klein*, D. Garkov, S. Rütschlin, T. Böttcher, F. Schreiber Database (2021) baab058. DOI: 10.1093/database/baab058
A Metabolite of Pseudomonas Triggers Prophage-Selective Lysogenic to Lytic Conversion in Staphylococcus aureus
J. Am. Chem. Soc. (2021) 143(22): 8344-8351. DOI: 10.1021/jacs.1c01275 Open Access, highlighted as Supplementary Cover
Inhibiting quinolone biosynthesis of Burkholderia
Chem. Sci. (2021) 12: 6908-6912. DOI: 10.1039/D0SC06167K Open Access, highlighted on the back cover
A ligand selection strategy identifies chemical probes targeting the proteases of SARS‐CoV‐2
Angew. Chem. Int. Ed. (2021) 60(12): 6799-6806. DOI: 10.1002/anie.202016113 Open Access
Unveiling the Hidden Theatre of Microbes. (Editorial)
ChemBioChem (2020) 21: 2869-2869. DOI: doi.org/10.1002/cbic.202000554
A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity
Cell Chem. Biol. (2020) 27: 817-826. DOI: 10.1016/j.chembiol.2020.06.004
Competitive profiling for enzyme inhibitors using chemical probes
Methods Enzymol. (2020) 633: 49-67. DOI: 10.1016/bs.mie.2019.10.031
Engineering Siderophores
Methods Enzymol. (2020) 633: 29-47. DOI: 10.1016/bs.mie.2019.10.030
Profiling Structural Diversity and Activity of 2-Alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia
Chem. Commun. (2020) 56: 6328-6331. DOI: 10.1039/D0CC02498H HOT Article, highlighted on the front cover
Competitive metabolite profiling of natural products reveals subunit specific inhibitors of the 20S proteasome.
ACS Cent. Sci. (2020) 6 (2): 241-246. DOI: 10.1021/acscentsci.9b01170 Open Access
The Multifaceted Inhibitory Effects of an Alkylquinolone on the Diatom Phaeodactylum tricornutum
ChemBioChem (2020) 21: 1206-1216 . DOI: 10.1002/cbic.201900612 Open Access
Inhibitors of Bacterial Swarming Behavior
Chem. Eur. J. (2020) 26(5): 964-979. DOI: 10.1002/chem.201901961 Highlighted as reviews showcase and frontpiece
Pseudo-biomineralisation: complex mineral structures shaped by microbes
ACS Biomater. Sci. Eng. (2019) 5(10): 5088-5096. DOI: 10.1021/acsbiomaterials.9b00387
A thiochromenone antibiotic derived from Pseudomonas quinolone signal selectively targets the Gram-negative pathogen Moraxella catarrhalis
Chem. Sci. (2019) 10: 6624-6628. DOI: 10.1039/C9SC01090D Highlighted in the 2019 HOT Article Collection
Close the ring to break the cycle: Tandem quinolone-alkyne-cyclisation gives access to tricyclic pyrrolo[1,2-a]quinolin-5-ones with potent anti-protozoal activity.
Chem. Commun. (2019) 55: 7009-7012. DOI: 10.1039/c9cc01689a Highlighted on the inside back cover
Competitive live-cell profiling strategy for discovering inhibitors of the quinolone biosynthesis of Pseudomonas aeruginosa
J. Am. Chem. Soc. (2018) 140 (43): 14019–14023. DOI: 10.1021/jacs.8b07629
Dissecting the mechanism of oligomerization and macro-cyclization reactions of NRPS independent siderophore synthetases.
Chem. Eur. J. (2018) 24: 16044-16051. DOI: 10.1002/chem.201803494 Highlighted as "hot paper" and cover feature
Eine vielseitige Enzymklasse für die Synthese ringförmiger Siderophore
BIO spektrum (2018) 05.18: 484-487. DOI: 10.1007/s12268-018-0950-5
Correlation of structural features of novel 1,2,3-triazoles with their neurotoxic and tumoricidal properties
Chem.-Biol. Interact. (2018) 291: 253-263. DOI: 10.1016/j.cbi.2018.06.029
A repeating sulfated galactan motif resuscitates dormant Micrococcus luteus
Appl. Environ. Microbiol. (2018) 84: e00745-18. DOI: 10.1128/AEM.00745-18
One Enzyme to Build Them All – Ring-Size Engineered Siderophores Inhibit Swarming Motility of Vibrio
ACS Chemical Biology (2018) 13(5): 1153-1158. DOI: 10.1021/acschembio.8b00084
From pirates and killers: Does metabolite diversity drive bacterial competition?
O rg. Biomol. Chem. (2018) 16: 2814-2819. DOI: 10.1039/c8ob00150b Highlighted on the journal front cover and in the HOT article collection
4-Quinolone N-oxides as bacterial weapons
(Synpacts) Synlett (2018) 29: 542-547. DOI: 10.1055/s-0036-1591913
From Molecules to Life: Quantifying the complexity of chemical and biological systems in the Universe
J . Mol. Evol. (2018) 86: 1-10. DOI: 10.1007/s00239-017-9824-6
An unsaturated quinolone N-Oxide of Pseudomonas aeruginosa modulates growth and virulence of Staphylococcus aureus
Angewandte Chemie Int. Ed. (2017) 56(25): 7271-7275. DOI: 10.1002/anie.201702944 Highlighted as “hot paper” and as journal front cover
Chemical probes for competitive profiling of quorum sensing signal synthase PqsD of Pseudomonas aeruginosa
Beilstein J. Org. Chem. (2016) 12: 2784-2792. DOI: 10.3762/bjoc.12.277
Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa
Chem. Commun . (2016) 52, 13440-13443. DOI: 10.1039/C6CC06295D Highlighted as journal front cover
An Additive Definition of Molecular Complexity
J. Chem. Inf. Model. (2016) , 56(3): 462-470. DOI: 10.1021/acs.jcim.5b00723
Dynamics of snake-like swarming behaviour of Vibrio alginolyticus
Biophys. J. (2016), 110(4): 981-992. DOI: 10.1016/j.bpj.2015.12.037
An aromatic hydroxyamide attenuates multiresistant Staphylococcus aureus toxin expression
Chem. Eur. J. (2016) , 22(5): 1622-1630. DOI: 10.1002/chem.201503981
Wie Bakterien uns mit Naturstoffen krank machen. Nachrichten aus der Chemie
Nachrichten aus der Chemie (2015), 63(12): 1163-1167. DOI: 10.1002/nadc.201590400
Phenyl esters are potent inhibitors of caseinolytic protease P and reveal a stereogenic switch for de-oligomerization
J. Am. Chem. Soc. (2015) , 137(26): 8457-8483. DOI: 10.1021/jacs.5b03084
A Chimeric Siderophore Halts Swarming Vibrio
Angewandte Chemie Int . Ed. (2014) 53(13): 3510-3513. DOI: 10.1002/anie.201310729
A β-Lactone-Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice
ChemMedChem (2014), 9(4):710-713. DOI: 10.1002/cmdc.201300325
Synthesis and Activity of Biomimetic Biofilm Disruptors
J. Am. Chem. Soc. (2013) 135(8): 2927-30. DOI: 10.1021/ja3120955
The mechanism of caseinolytic protease (ClpP) inhibition
Angewandte Chemie Int. Ed. (2013), 52(10): 3009-3014. DOI: 10.1002/anie.201204690
β-Lactams and β-lactones as activity-based probes in chemical biology
Med. Chem. Comm. (2012), 3: 408-417. DOI: 10.1039/c2md00275b
Development and characterization of improved β-lactone-based anti-virulence drugs targeting ClpP
Bioorg. Med. Chem. (2012), 20(2): 583-591. DOI: 10.1016/j.bmc.2011.07.047
Vibralactone as a tool to unravel the activity and structure of the ClpP1P2 complex from Listeria monocytogenes
Angewandte Chemie Int. Ed. (2011), 50(46): 11001-11004. DOI: 10.1002/anie.20
Identification of Acyl Protein Thioesterase 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M
Angewandte Chemie Int. Ed. (2011), 50(42): 9838-9842. DOI: 10.1002/anie.201102967
A conformational switch underlies ClpP protease function
Angewandte Chemie Int. Ed. (2011), 50(25): 5749-5752. DOI: 10.1002/anie.201100666 Highlighted as “hot paper”
Protein reactivity of natural product derived γ-butyrolactones
Biochemistry (2011), 50 (5): 910-916. DOI: 10.1021/bi101858g
The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds
Chem. Commun. (2010), 46: 8475-8477. DOI: 10.1039/c0cc02825h
A cyanobacterial serine protease of Plasmodium falciparum is targeted to the apicoplast and plays an important role in its growth and development
Mol. Microbiol. (2010), 77(6): 873-890. DOI: 10.1111/j.1365-2958.2010.07251.x
Natural products and their biological targets: proteomic and metabolomic labeling strategies
Angewandte Chemie Int. Ed. (2010), 49(15): 2680-2698. DOI: 10.1002/anie.200905352
Showdomycin as a versatile chemical tool for the detection of pathogenesis associated enzymes in bacteria
J. Am. Chem. Soc. (2010), 132(20): 6964-72. DOI: 10.1021/ja909150y
Small Molecules as Versatile Tools for Activity-Based Protein Profiling Experiments
In: Comprehensive Natural Products II: Chemistry and Biology, Vol. 9: Modern Methods for the Investigation of Natural Products (2010), p. 629-674, Ed. Lew Mander, Hung-Wen Liu, Elsevier, ISBN: 9780080453811. DOI: 10.1016/B978-008045382-8.00159-3
Naturstoffe und ihre Derivate als molekulare Sonden: Identifikation ihrer Angriffsziele und Inhibition der Virulenz in pathogenen Bakterien
Verlag Dr. Hut, München (2010). ISBN: 978-3-86853-331-6. DOI: 10.5282/edoc.11018
The HADES mission concept – astrobiological survey of Jupiter's icy moon Europa
Int. J. Astrobiol. (2009), 8(4): 321-329. DOI: 10.1017/S147355040999022X
β-Lactones Decrease the Intracellular Virulence of Listeria monocytogenes in Macrophages
ChemMedChem (2009), 4(8):1260-1263. DOI: 10.1002/cmdc.200900157
Structurally refined beta-lactones as potent inhibitors of devastating bacterial virulence factors
ChemMedChem (2009),10(4):663-666. DOI: 10.1002/cbic.200800743
Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus
J. Am. Chem. Soc. (2008), 130(44): 14400-14401. DOI: 10.1021/ja8051365
Beta-lactones as privileged structures for the active-site labeling of versatile bacterial enzyme classes
Angewandte Chemie Int. Ed. (2009), 47(24): 4600-4603. DOI: 10.1002/anie.200705768
The fate of isoproturon in a freshwater microcosm with Lemna minor as a model organism
Chemosphere (2007), 66: 684-689. DOI: 10.1016/j.chemosphere.2006.07.087